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    <ns1:identifier>o:9692</ns1:identifier>
    <ns1:title language="sr">Magnetna rezonancija dojki : morfološki i kinetički parametri u proceni odgovora karcinoma dojke na neoadjuvantnu hemioterapiju </ns1:title>
    <ns2:subtitle language="sr">doktorska disertacija</ns2:subtitle>
    <ns2:alt_title language="en">Breast Magnetic Resonance Imaging: Morphologic and Kinetic Parameters in the Evaluation of Breast Carcinoma Response to Neoadjuvant Chemotherapy : doctoral dissertation</ns2:alt_title>
    <ns1:language>sr</ns1:language>
    <ns1:description language="sr">Uloga hemioterapijskih protokola primenjenih u neoadjuvantnoj terapiji
karcinoma dojke (NACT), podrazumeva indukovanje regresije tumora pre primene
hirurškog modaliteta lečenja, kao i sterilizaciju mikrometastatskih fokusa. Praćenje
odgovora omogućava ranu procenu efikasnosti NACT. Postizanje patološkog
kompletnog odgovora (pCR) nakon primenjene NACT, u korelaciji je sa produženim
ukupnim preživljavanjem (OS). Savremeni pristup u izboru specifične onkološke
terapije podrazumeva maksimalni efekat u postizanju pCR. Postoji potreba
standardizovanja primene senzitivne i specifične radiološke metode za ranu procenu
odgovora tumora na NACT, već nakon primene drugog terapijskog ciklusa, kako bi se
identifikovale ispitanice kod kojih postoji rani tumorski odgovor.
Praćenje odgovora na NACT, moguće je na osnovu praćenja predefinisanih
morfološko – dinamskih parametara magnetne rezonanciju dojki (MRI), kao što je
promena najveće dimenzije tumora, promena volumena izračunatog na osnovu
matematičkog modela, koji uzima u obzir tri dimenzije tumora, procenu tipa tumorske
regresije i procenu dinamskih svojstava lezije.
Cilj
1. Procena tačnosti postupaka merenja veličine tumora prikazanog
MRI – RECIST, volumetrijska metoda, a u odnosu na
patohistološku veličinu tumora i odgovor.
2. Procena promene morfologije tumora – tip tumorske regresije
(dendritični ili koncentrični tip) u proceni tumorskog odgovora na
NACT.
3. Procena dinamskih karakteristika tumora kao parametra
neoangiogeneze... </ns1:description>
    <ns1:description language="en">The role of neoadjuvant chemotherapy (NACT) in breast cancer treatment is
to induce tumor regression before surgery, including the sterilization of micro
metastatic foci. Evaluation of tumor response to treatment provides the early
assessment of NACT efficacy. Pathological complete response (pCR) upon the
completion of NACT correlates with the prolongation of the overall survival (OS).
The up-to-date therapeutic approach in breast cancer treatment aims at maximizing
the effect of pCR achievement. There is however the need to standardize the highly
sensitive and specific imaging method for early assessment of tumor response to
NACT – upon the completion of the 2nd cycle of NACT, so that the histologic
responders could be identified.
The assessment of tumor response to NACT is achieved through the selection
and analysis of the predefined morphologic and dynamic parameters – endpoints
evaluated with the dynamic contrast enhanced breast MRI that include: the change of
the largest tumor size, the change of the tumor volume defined with the mathematical
model taking into account the three tumor dimensions, tumor shrinkage pattern and
dynamic features of the lesion.
Aim 1. Assessment of the tumor size and volume measurement accuracy with MRI,
taking into account the measuring tools: RECIST and volume, in relation to
the pathological tumor size and response.
2. Assessment of the change of morphologic tumor features – shrinkage pattern
(dendritic vs. concentric) as the measure of tumor response to NACT.
3. Assessment of dynamic tumor features as the endpoint reflecting tumor
neoangiogenesis...</ns1:description>
    <ns1:description language="sr">Medicina - Radiologija / Scientific field:Medicine - Radiology 
Datum odbrane : 22.12.2014 </ns1:description>
    <ns1:keyword language="sr">karcinom dojke, magnetna rezonancija, neoadjuvantna hemioterapija</ns1:keyword>
    <ns1:keyword language="en">breast carcinoma, magnetic resonance imaging, neoadjuvant chemotherapy</ns1:keyword>
    <ns1:keyword language="sr">616-006</ns1:keyword>
    <ns2:irdata>yes</ns2:irdata>
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      <ns2:identifier>1956</ns2:identifier>
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    <ns1:upload_date>2015-09-10T10:39:32.053Z</ns1:upload_date>
    <ns1:status>45</ns1:status>
    <ns2:peer_reviewed>no</ns2:peer_reviewed>
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      <ns1:role>46</ns1:role>
      <ns1:ext_role>mentor</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Mirjan M., 1974- </ns3:firstname>
        <ns3:lastname>Nadrljanski</ns3:lastname>
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        <ns3:firstname> Ružica, 1962- </ns3:firstname>
        <ns3:lastname>Maksimović</ns3:lastname>
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        <ns3:firstname> Zorica, 1957- </ns3:firstname>
        <ns3:lastname>Milošević</ns3:lastname>
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        <ns3:firstname> Vesna, 1958- </ns3:firstname>
        <ns3:lastname>Plešinac Karapandžić</ns3:lastname>
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      <ns1:ext_role>član komisije</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Irini, 1952- </ns3:firstname>
        <ns3:lastname>Reljin</ns3:lastname>
      </ns1:entity>
      <ns1:date>2014</ns1:date>
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    <ns7:description language="sr">Medicina - Radiologija / Scientific field:Medicine - Radiology </ns7:description>
    <ns7:keyword language="sr" seq="0">karcinom dojke, magnetna rezonancija, neoadjuvantna hemioterapija</ns7:keyword>
    <ns7:keyword language="en" seq="1">breast carcinoma, magnetic resonance imaging, neoadjuvant chemotherapy</ns7:keyword>
    <ns7:keyword language="sr" seq="2">616-006</ns7:keyword>
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