o:39995 Comprehensive Review of Extracellular Vesicles in Thyroid Cancer: From Methodological Approaches to Biological Functions and Clinical Applications en ABSTRACT Thyroid cancer (TC) is one of the most common endocrine malignancies and ranks among the ten most frequently diagnosed cancers worldwide, highlighting the need for improved diagnostic and monitoring strategies. Extracellular vesicles (EVs) are nano-sized, membrane-enclosed particles released by nearly all cell types that carry selectively sorted bioactive cargo capable of influencing the behavior and fate of recipient cells. Although their molecular composition is shaped by their cells of origin, cargo loading is a regulated process that contributes to EV-mediated intercellular communication and cell-specific targeting. In TC, EVs have emerged as important mediators of tumor progression and microenvironment modulation. EVs, exosomes, biomarkers, non-coding RNA, protein, liquid biopsy, diagnosis, prognosis, prediction, therapy 1552099 10.3390/ijms27167337 1552101 1422-0067 2026-10-13T08:23:58.049Z 44 yes 46 Sonja Šelemetjev University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka 0000-0002-2898-6671 Ninoslav Mitić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0003-2756-6517 Tijana Išić Denčić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-8475-2266 application/pdf 6579962 https://phaidrabg.bg.ac.rs/o:39995 no yes 16 70 92000002 11A29 The International Journal of Molecular Sciences 27 16 7337 MDPI, Basel, Switzerland 2026