Comprehensive Review of Extracellular Vesicles in Thyroid Cancer: From Methodological Approaches to Biological Functions and Clinical Applications Šelemetjev, Sonja Mitić, Ninoslav Išić Denčić, Tijana The International Journal of Molecular Sciences volume: 27 number: 16 startpage: 7337 application/pdf 6579962 bytes 2026 EVs, exosomes, biomarkers, non-coding RNA, protein, liquid biopsy, diagnosis, prognosis, prediction, therapy MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/4.0/legalcode eng ABSTRACT Thyroid cancer (TC) is one of the most common endocrine malignancies and ranks among the ten most frequently diagnosed cancers worldwide, highlighting the need for improved diagnostic and monitoring strategies. Extracellular vesicles (EVs) are nano-sized, membrane-enclosed particles released by nearly all cell types that carry selectively sorted bioactive cargo capable of influencing the behavior and fate of recipient cells. Although their molecular composition is shaped by their cells of origin, cargo loading is a regulated process that contributes to EV-mediated intercellular communication and cell-specific targeting. In TC, EVs have emerged as important mediators of tumor progression and microenvironment modulation. https://phaidrabg.bg.ac.rs/o:39995 doi:10.3390/ijms27167337 ISSN: 1422-0067 info:eu-repo/semantics/review