o:39769 Correlation between mRNA expression of IL-1β, IL-8, TNFα, IL-6 and IL-10 in PBMCs and redox status parameters in GDM en ABSTRACT Gestational diabetes mellitus (GDM) is characterized by chronic low-level inflammation and oxidative stress, both of which contribute to disease pathogenesis. Cytokines expressed in peripheral blood mononuclear cells (PBMCs) may reflect the inflammatory status associated with redox alterations. This study aimed to investigate the correlations between the expression of IL-1β, IL-8, TNFα, IL-6 and IL-10 in PBMCs and selected oxidative stress parameters in women with GDM. Redox status was assessed by measuring the activities of the antioxidant enzymes glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT), serum thiol content, expression of NRF2, as well as protein carbonyl (PCO) levels and TBARS as markers of oxidative biomacromolecular damage. Cytokines, redox status, GDM, SOD, protein carbonyl levels 1552100 978-86-82679-23-3 2026-09-22T10:57:14.682Z 44 yes 46 Jovana Stevanović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia 0000-0002-3619-8472 Iva Vasiljević Faculty of Biology, University of Belgrade, Serbia person Ana Penezić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-2539-4507 Milica Mandić Gynecology and Obstetrics Clinic “Narodni Front”, Belgrade, Serbia person Dragana Maglić Gynecology and Obstetrics Clinic “Narodni Front”, Belgrade, Serbia person Vesna Mandić-Marković Faculty of Medicine, University of Belgrade, Serbia person Miloš Brkušanin Faculty of Biology, University of Belgrade, Serbia person Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-2042-0056 Zorana Dobrijević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor nauka-biološke nauke person 0000-0002-4652-7719 application/pdf 663815 https://phaidrabg.bg.ac.rs/o:39769 no yes 16 70 92000004 11A29 11A2905 11A02 11A32 Book of abstracts – BeCELS 2026: Belgrade Conference for Early-Career Life Scientists Institut za molekularnu genetiku i genetičko inženjerstvo, Univerzitet u Beogradu, Beograd, Srbija 2026