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    <ns1:title language="en">Taxifolin inhibits endovascular differentiation of human trophoblast cells</ns1:title>
    <ns1:language>en</ns1:language>
    <ns1:description language="en">ABSTRACT
Taxifolin (TF) is a bioactive flavonoid with various pharmacological effects including antioxidant, anti-inflammatory, hepatoprotective and anti-cancer activities1. It can be extracted from different coniferous trees, and it is present in various plants used in traditional medicine as well as
in different commercially available health-promoting products1. Also, TF can be found in vegetables, fruits and beverages used in everyday diet [1]. Previously, TF showed cytoprotective, antioxidant and anti-inflammatory activity on trophoblast cells, specialized cells of placenta [2,3], but its effect on function of these cells has not yet been studied. Successful pregnancy largely
depends on adequate placentation including remodeling of uterine spiral arteries during which
extravillous (EVT) trophoblast cells acquire endothelial-like properties.</ns1:description>
    <ns1:keyword language="en">taxifolin; extravillous trophoblast; HTR-8/SVneo cells; endovascular differentiation; VE-cadherin; angiogenesis</ns1:keyword>
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