ABSTRACT Taxifolin (TF) is a bioactive flavonoid with various pharmacological effects including antioxidant, anti-inflammatory, hepatoprotective and anti-cancer activities1. It can be extracted from different coniferous trees, and it is present in various plants used in traditional medicine as well as in different commercially available health-promoting products1. Also, TF can be found in vegetables, fruits and beverages used in everyday diet [1]. Previously, TF showed cytoprotective, antioxidant and anti-inflammatory activity on trophoblast cells, specialized cells of placenta [2,3], but its effect on function of these cells has not yet been studied. Successful pregnancy largely depends on adequate placentation including remodeling of uterine spiral arteries during which extravillous (EVT) trophoblast cells acquire endothelial-like properties. Vilotić, Aleksandra Ilić, Gorana Pirković, Andrea Jovanović Krivokuća, Milica 2026 info:eu-repo/semantics/abstract Book of Abstracts-First International Conference on Medical, Pharmaceutical and Cosmetic Chemistry, Household and Industrial Chemistry, Forensic and Analytical Chemistry-ChemInno 2026 application/pdf 3927280 bytes https://phaidrabg.bg.ac.rs/o:39511 ISBN: 978-86-908815-2-9 http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode eng Institut za opštu i fizičku hemiju, Studentski trg 12-16, Beograd, Srbija Taxifolin inhibits endovascular differentiation of human trophoblast cells taxifolin; extravillous trophoblast; HTR-8/SVneo cells; endovascular differentiation; VE-cadherin; angiogenesis