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    <ns1:title language="en">Thyroid-Originating Extracellular Vesicles Harbor Thyroid-Specific Biomarkers with Potential Relevance for Thyroid Cancer Recurrence Detection</ns1:title>
    <ns1:language>en</ns1:language>
    <ns1:description language="en">ABSTRACT
Thyroid cancer (TC) is the most common endocrine malignancy, and challenges persist in preoperative diagnosis of indeterminate nodules and postoperative monitoring when
thyroglobulin (Tg) assays are compromised by interfering anti-Tg antibodies (Tg-Ab). Extracellular vesicles (EVs) carry molecular cargo reflective of cells of origin and are increasingly explored as biomarker sources. In this study, we investigated whether thyroid derived EVs retain the expression of thyroid-specific thyrotropin-receptor (TSHR), a suitable target in immunoaffinity-based EV isolation, and explored the presence of Tg in EV cargo as potential surrogate for serum Tg.</ns1:description>
    <ns1:keyword language="en">extracellular vesicles; thyroid cancer; recurrent thyroid cancer; thyrotropin-receptor; TSHR; thyroglobulin; thyroid cell lines; human plasma</ns1:keyword>
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      <ns2:identifier>10.3390/ijms27083510</ns2:identifier>
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        <ns3:firstname>Ninoslav</ns3:firstname>
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        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade,  Serbia</ns3:institution>
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        <ns3:firstname>Jelena</ns3:firstname>
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    <ns12:name_magazine language="en">International Journal of Molecular Sciences</ns12:name_magazine>
    <ns12:volume>27</ns12:volume>
    <ns12:booklet>8</ns12:booklet>
    <ns12:publisher>MDPI, Švajcarska</ns12:publisher>
    <ns12:releaseyear>2026</ns12:releaseyear>
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