https://phaidrabg.bg.ac.rs/o:39247 doi:10.3390/ijms27083510 Thyroid-Originating Extracellular Vesicles Harbor Thyroid-Specific Biomarkers with Potential Relevance for Thyroid Cancer Recurrence Detection application/pdf 2146924 bytes ABSTRACT Thyroid cancer (TC) is the most common endocrine malignancy, and challenges persist in preoperative diagnosis of indeterminate nodules and postoperative monitoring when thyroglobulin (Tg) assays are compromised by interfering anti-Tg antibodies (Tg-Ab). Extracellular vesicles (EVs) carry molecular cargo reflective of cells of origin and are increasingly explored as biomarker sources. In this study, we investigated whether thyroid derived EVs retain the expression of thyroid-specific thyrotropin-receptor (TSHR), a suitable target in immunoaffinity-based EV isolation, and explored the presence of Tg in EV cargo as potential surrogate for serum Tg. 2026 MDPI, Švajcarska extracellular vesicles; thyroid cancer; recurrent thyroid cancer; thyrotropin-receptor; TSHR; thyroglobulin; thyroid cell lines; human plasma Bobar, Nevena Mitić, Ninoslav Kosanović, Maja Šelemetjev, Sonja Išić Denčić, Tijana Taušanović, Katarina Janković Miljuš, Jelena eng info:eu-repo/semantics/article http://creativecommons.org/licenses/by/4.0/legalcode International Journal of Molecular Sciences volume: 27 number: 8