o:36791 Bioaktivni materijali na bazi kalcijum-fosfata i mezoporoznog biostakla dopiranih jonima magnezijuma i/ili stroncijuma doktorska disertacija Bioactive materials based on calcium phosphates and mesoporous bioglass ion-doped with magnesium and/or strontium: synthesis, processing, characterization and biomedical application : doctoral dissertation sr U okviru ove doktorske disertacije sintetisani su i ispitani prahovi na bazi kalcijum-fosfata(CaP) i mezoporoznog bioaktivnog stakla (MBAG) dopirani jonima magnezijuma (Mg2+) i/ilistroncijuma (Sr2+). Različitim metodama procesiranja, a polazeći od sintetisanih prahova, dobijeni sukontrolisano porozni kompakti i makroporozni nosači ćelija, a u nastavku je ispitan njihov potencijalza primenu u stomatologiji i biomedicini.Pokazano je da istovremeno prisustvo jona Sr2+ i Mg2+ u strukturi hidroksiapatita (HAP)destabiliše HAP rešetku, rezultujući bifaznim CaP sastavom, dok prilikom sinterovanja stabiliše b-TCP fazu odlaganjem transformacije u a-TCP. Najbolja mehanička svojstva su potvrđena kodSrMgHAP uzorka dopiranog sa po 3 mol.% Sr2+ i Mg2+ (5,02 GPa i 1,12 MPa‧m1/2).Sferne nanočestice SrMgMBAG su uspešno sintetisane mikroemulzionom tehnikom. Binarnodopiranje je uticalo na stvaranje radijalne dendritske mezoporozne strukture, što je ubrzalo otpuštanjeleka ibuprofena u poređenju sa nedopiranim česticama.Procesirani kompakti kotrolisane poroznosti na bazi dopiranih HAP su ispitani za primenu ustomatologiji u vidu dentalnih inserata. Predložen je novi protokol za restauraciju velikih kavitetazuba korišćenjem dentalnih inserata na bazi HAP. Ekstrahovani ljudski molari restauriranikorišćenjem konvencionalnog postupka i primenom novopredloženog protokola su imali sličnuotpornost na lom.Dobijeni makroporozni nosači ćelija na bazi SrMgCaP i njihovi kompoziti sa MBAGpredstavljaju adekvatne nosače ćelija za primenu u inženjerstvu koštanog tkiva, omogućuju dobruadheziju i proliferaciju BM-MSC i EA.hy926 ćelija, ali i pokazuju pro-osteogena i pro-angiogenasvojstva. Nanošenje biorazgradive biokompozitne prevlake na bazi želatina i čestica Sr,MgMBAG jeznačajno poboljšalo pritisnu čvrstoću makroporoznih nosača. Within this doctoral dissertation powders based on calcium phosphates (CaP) and mesoporousbioactive glass (MBAG) doped with magnesium (Mg2+) and/or strontium (Sr2+) ions weresynthesized. Using various techniques the obtained powders were processed in the form of compactswith controlled porosity, or scaffolds, and their possible biomedical or dental application wasevaluated.It was shown that simultaneous presence of Sr2+ and Mg2+ in the hydroxyapatite (HAP)structure destabilizes the HAP lattice resulting in the biphasic CaP composition, while also stabilizingthe b-TCP phase during sintering by postponing its transformation into a-TCP. The best mechanicalproperties were obtained in the case of SrMgHAP doped with 3 mol.% of Sr2+ and Mg2+ (5,02 GPa i1,12 MPa‧m1/2).Spherical SrMgMBAG nanoparticles were successfully synthesized using microemulsion sol-gel technique. The binary doping influenced formation of radial dendritic mesoporous structure,which increased the rate of ibuprofen drug release, compared to pristine particles.Obtained compacts with controlled porosity based on doped HAP were analyzed forapplication in dentistry as dental inserts. A novel protocol for restoration of large tooth cavities usingdental inserts based on HAP was proposed. Extracted human molars were restored using convectionaland novel protocols, and their fracture resistance was shown to be similar.Fabricated scaffolds based on SrMgCaP and their composites with MBAG were shown to beadequate cell carriers for application in bone tissue engineering, by showing good cells adhesion andproliferation of BM-MSC and EA.hy926 cells, as well as pro-osteogenic and pro-angiogenicproperties. Coating the scaffolds with biodegradable biocomposites based on gelatine andSrMgMBAG particles showed significantly improved compressive strength of the scaffolds Tehnološko inženjerstvo - Inženjerstvo materijala / Technological engineering -Materials Engineering Datum odbrane: 22.05.2025. kalcijum-fosfati; mezoporozno bioaktivno staklo; dentalni insert; skafoldi calcium phosphates; mesoporous bioactive glass; dental insert; scaffold 91552100 176971017 91552101 9910 2025-10-20T10:24:25.053Z 45 no 46 Tamara Z., 1994- Matić 129491721 2024 63 mentor Đorđe, 1977- Veljović 35716455 2024 63 član komisije Đorđe, 1964- Janaćković 12659559 2024 63 član komisije Rada, 1965- Petrović 12699495 2024 63 član komisije Maja, 1984- Ležaja-Zebić 93976841 2024 63 član komisije Lia Rimondini 130064393 2024 122 str. 45452895 http://phaidrabg.bg.ac.rs/o:36791 no yes 12 2025-10-20T10:24:25.320Z 70 11 1067197 1067378 1067401 11 1067197 1067198 1067214 kalcijum-fosfati; mezoporozno bioaktivno staklo; dentalni insert; skafoldi calcium phosphates; mesoporous bioactive glass; dental insert; scaffold 666.1.017:616.314-74(043.3) 1738 11A41 2024