application/pdf 94152 bytes eng info:eu-repo/semantics/article Trichinella spiralis-derived extracellular vesicles induce regulatory T cells and reduce airway allergy in mice Frontiers Trichinella spiralis, extracellular vesicles, respiratory allergy, regulatory T cells, immune modulation, allergic inflammation ABSTRACT Introduction: Respiratory allergies are an increasing global health concern, with current treatments primarily targeting symptoms rather than underlying immune dysregulation. Trichinella spiralis derived extracellular vesicles (TsEVs) have been implicated in modulating immune responses, but their role in allergic airway inflammation remains unexplored. This study investigates the immunomodulatory potential of TsEVs in mitigating ovalbumin (OVA)-induced allergic airway inflammation in mice. Methods: TsEVs were isolated from T. spiralis muscle larvae excretory-secretory products and characterized using nanoparticle tracking analysis. 2025 https://phaidrabg.bg.ac.rs/o:36457 doi:10.3389/fimmu.2025.1637569 http://creativecommons.org/licenses/by/4.0/legalcode Glamočlija, Sofija Kosanović, Maja Schabussova, Irma Wiedermann, Ursula Inić-Kanada, Aleksandra Vasilev, Saša Gruden-Movsesijan, Alisa Radulović, Nataša Schmid, Anna Sabljić, Ljiljana Frontiers in Immunology