o:36450 Diabetes mellitus type 2 may reduce the activity of albumin-bound food antioxidants Dijabetes melitus tipa 2 može smanjiti aktivnost antioksidanata u hrani vezanih za albumin en ABSTRACT Dietary interventions based on antioxidants are a cornerstone in the management of diabetes mellitus type 2 (DM2). Pharmacokinetic factors, such as antioxidant interaction with plasma albumin, however, may influence their activity. Albumin modification due to glycooxidation may additionally affect antioxidant-albumin association [1]. The aim of the study was to examine binding effects of three pronounced antioxidants present in the Mediterranean diet: resveratrol, (dihydro)lipoic acid and oleuropein using albumin isolated from patients with DM2 and healthy persons. Average fluorescence spectra of the isolated albumin from two study groups were similar, whereas relative amounts of advanced glycation endproducts and dityrosines were greater in albumin isolated from patients. Calculated binding constants were similar for two study groups for all three ligands. diabetes mellitus type 2 (DM2), food antioxidants, albumin 1552100 978-86-7834-453-4 91552100 COBISS.SR-ID 171246857 2025-08-06T08:06:46.539Z 44 yes 46 Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka 0000-0003-2042-0056 Dragana Dekanski University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor medicine-doktor medicinskih nauka person 0000-0001-8467-4165 Miloš Šunderić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-0940-9481 application/pdf 836564 https://phaidrabg.bg.ac.rs/o:36450 no yes 18 70 92000004 11A29 3rd European Symposium on Phytochemicals in Medicine and Food-1-4 July, 2025, Belgrade, Serbia University of Belgrade-Faculty of Agriculture, Belgrade, Serbia 2025