diabetes mellitus type 2 (DM2), food antioxidants, albumin University of Belgrade-Faculty of Agriculture, Belgrade, Serbia Diabetes mellitus type 2 may reduce the activity of albumin-bound food antioxidants application/pdf 836564 bytes 3rd European Symposium on Phytochemicals in Medicine and Food-1-4 July, 2025, Belgrade, Serbia Nedić, Olgica Dekanski, Dragana Šunderić, Miloš https://phaidrabg.bg.ac.rs/o:36450 cobiss:COBISS.SR-ID 171246857 ISBN: 978-86-7834-453-4 ABSTRACT Dietary interventions based on antioxidants are a cornerstone in the management of diabetes mellitus type 2 (DM2). Pharmacokinetic factors, such as antioxidant interaction with plasma albumin, however, may influence their activity. Albumin modification due to glycooxidation may additionally affect antioxidant-albumin association [1]. The aim of the study was to examine binding effects of three pronounced antioxidants present in the Mediterranean diet: resveratrol, (dihydro)lipoic acid and oleuropein using albumin isolated from patients with DM2 and healthy persons. Average fluorescence spectra of the isolated albumin from two study groups were similar, whereas relative amounts of advanced glycation endproducts and dityrosines were greater in albumin isolated from patients. Calculated binding constants were similar for two study groups for all three ligands. 2025 info:eu-repo/semantics/conferenceProceedings http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode eng