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    <ns1:title language="en">Trophoblast Extracellular Vesicles as Modulators of Keratinocyte Stress Response and Senescence</ns1:title>
    <ns1:language>en</ns1:language>
    <ns1:description language="en">ABSTRACT
Keratinocyte stress, caused by various intrinsic and extrinsic factors, contributes to the overall aging process. D-galactose-induced metabolic/oxidative stress is a commonly used in vitro model for studying premature aging. Due to their rich composition of bioactive molecules that influence critical pathways in cellular aging and rejuvenation, placental derivatives have a well- established history in anti-aging skincare and therapy. However, trophoblast-derived extracellular vesicle (TEV) effects on D-galactose-induced premature aging in keratinocytes have not been investigated yet.</ns1:description>
    <ns1:keyword language="en">skin; aging; placenta; wound healing; regenerative medicine</ns1:keyword>
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