https://phaidrabg.bg.ac.rs/o:36384 doi:10.3390/life15060918 ABSTRACT Keratinocyte stress, caused by various intrinsic and extrinsic factors, contributes to the overall aging process. D-galactose-induced metabolic/oxidative stress is a commonly used in vitro model for studying premature aging. Due to their rich composition of bioactive molecules that influence critical pathways in cellular aging and rejuvenation, placental derivatives have a well- established history in anti-aging skincare and therapy. However, trophoblast-derived extracellular vesicle (TEV) effects on D-galactose-induced premature aging in keratinocytes have not been investigated yet. Nacka-Aleksić, Mirjana Pirković, Andrea Vilotić, Aleksandra Kosanović, Maja Dekanski, Dragana Legner, Janko Jovanović Krivokuća, Milica application/pdf 1910269 bytes info:eu-repo/semantics/article http://creativecommons.org/licenses/by/4.0/legalcode skin; aging; placenta; wound healing; regenerative medicine Life volume: 15 number: 6 startpage: 918 Trophoblast Extracellular Vesicles as Modulators of Keratinocyte Stress Response and Senescence 2025 eng MDPI, Basel, Switzerland