2023 S. Karger AG, Basel eng info:eu-repo/semantics/article https://phaidrabg.bg.ac.rs/o:36382 doi:10.1159/000535120 Cvetković, Jelena Jacobi, Ronald H.J. Miranda-Bedate, Alberto Pham, Nhung Kutmon, Martina Groot, James van de Garde, Martijn D.B. Pinelli, Elena ABSTRACT Introduction: A role for innate immune memory in protection during COVID-19 infection or vaccination has been recently reported. However, no study so far has shown whether the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can train innate immune cells. The aim of this study was to investigate whether this virus can induce trained immunity in human monocytes. Methods: Monocytes were exposed to inactivated SARS-CoV-2 (iSARS-CoV-2) for 24 h, followed by a resting period in the medium only and a secondary stimulation on day 6 after which the cytokine/chemokine and transcriptomic profiles were determined. application/pdf 1151977 bytes Human Monocytes Exposed to SARS-CoV-2 Display Features of Innate Immune Memory Producing High Levels of CXCL10 upon Restimulation Journal of Innate Immunity volume: 15 number: 1 startpage: 911 endpage: 924 Trained immunity, Severe acute respiratory syndrome coronavirus 2, CXCL10, Monocytes http://creativecommons.org/licenses/by-nc/4.0/legalcode