o:36372 miR-27a-3p, miR-222-3p and miR-340-5p as indicators of the antioxidant response activation in gestational diabetes miR-27a-3p, miR-222-3p i miR-340-5p kao indikatori aktivacije antioksidativnog odgovora u gestacijskom dijabetesu en ABSTRACT Background: Gestational diabetes (GDM) is the most common pregnancy related metabolic disorder and a major risk factor for both mother and a child, during pregnancy and after delivery. Impairment of the anti-oxidative system acts as the driving force of the devastating consequences in GDM, while microRNA molecules are affected by disturbances related to (glyco)oxidative stress ((g)OS) and emerged as potential sensors and effectors of (g)OS-associated mechanisms. Aims: The aim of the present study was to evaluate the potential of OS-related microRNAs miR-27a, miR222 and miR-340 from peripheral blood mononuclear cells (PBMCs) to serve as OS indicators of in GDM. microRNA; pregnancy; glutathione reductase; thiol content; Superoxide dismutase; zinc 1552099 10.1007/s11033-025-10778-8 1552102 https://link.springer.com/article/10.1007/s11033-025-10778-8 2025-07-02T10:19:19.528Z 44 yes 46 Ana Penezić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka 0000-0002-2539-4507 Daniela Ardalić University Clinic for Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia person Vesna Mandić-Marković University of Belgrade, Medical School, Belgrade, Serbia person Željko Miković University of Belgrade, doMedical School, Belgrade, Serbia person Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-2042-0056 Zorana Dobrijević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-4652-7719 Miloš Šunderić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-0940-9481 Goran Miljuš University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0001-6417-8711 Dragana Robajac University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-6423-4645 Jovana Stevanović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person 0000-0002-3619-8472 Ognjen Radojičić University Clinic for Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia person application/pdf 1021100 https://phaidrabg.bg.ac.rs/o:36372 no yes 1 70 92000001 11A29 11A2905 11A32 Accepted version © All rights reserved Molecular Biology Reports 52 Springer Nature Link 2025