o:36135 Storage stability of the liposomal system with encapsulated Vaccinium myrtillus extract en Vaccinium myrtillus fruits and leaves show significant economic importance due to their application in food, functional food, pharmaceutical, cosmetic, and healthcare products. Bilberry leaves contain valuable components, such as phenolic acids, flavonoids, procyanidins, anthocyanins, fatty acids, and dietary fibers. The mentioned compounds possess various biological potentials, including antioxidant, anti-inflammatory, antimicrobial, regenerative, astringent, lipid-lowering, and anti-diabetic properties. With the aim of improving storage stability, biodistribution, and bioavailability, as well as providing controlled release of bioactive compounds, V. myrtillus extract was encapsulated in the liposomal vesicles, and their storage stability and stability after UV irradiation were monitored. Vesicle size, polydispersity index (PDI), and zeta potential were determined in the 60-day storage study at 4°C. The liposome size varied in a narrow range. PDI values were between 0.294 and 0.338 (for the non-treated sample) and 0.249 and 0.437 (for the UV-irradiated sample). The zeta potential was -5.02 mV on the 1st day and -9.16 mV on the 60th day for non-treated liposomes, while for UV-irritated, the zeta potential amounted to -3.93 mV on the 1st day and -8.22 mV on the 60th day. In both types of the sample, there was no significant change in the vesicle size during storage, while the zeta potential (absolute value) increased. Additionally, the PDI value increased in the UV-irradiated liposomes. The beneficial effects of bioactive principles from bilberry leaf on human health highlight the application of liposomes as a carrier for its extract and their potential implementation in food, functional food, pharmaceutical, and cosmetic formulations. bilberry, liposomal particles, polydispersity index, storage stability, zeta potential 1552100 978-99955-81-52-7 2025-04-22T10:51:24.480Z 44 yes 46 Amjed Karkad University of Belgrade Faculty of Technology and Metallurgy Muna Elferjane University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, Belgrade, Serbia person Milena Milošević University of Belgrade, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, Serbia person Andrea Pirković University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-1182-4895 Diana Lupulović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor veterinarskih nauka person 0000-0002-2476-4887 Aleksandar Marinković University of Belgrade, Faculty of Technology and Metallurgy, Serbia person Aleksandra A. Jovanović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor tehnoloških nauka person 0000-0001-5394-0125 application/pdf 4378173 https://phaidrabg.bg.ac.rs/o:36135 no yes 19 70 92000004 11A41 11A29 Storage stability of the liposomal system with encapsulated Vaccinium myrtillus extract 58 58 Proceedings of the IX International Congress “Engineering, Environment and Materials in Process Industry” – EEM2025 Ethno Village Stanišići, Bosnia and Herzegovina Faculty of Technology, University of East Sarajevo 2025