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    <ns1:identifier>o:36087</ns1:identifier>
    <ns1:title language="en">Interactions of Trichinella spiralis mucle larvae extracellular vesicles with target cells and their mechanisms of action</ns1:title>
    <ns1:language>en</ns1:language>
    <ns1:description language="en">ABSTRACT
Introduction: The parasite Trichinella spiralis induces a tolerogenic immune microenvironment in its host, which also leads to the alleviation of chronic inflammatory diseases. This effect is exerted by excretory–secretory products of the muscle larvae (ES L1), with extracellular vesicles (TsEVs) being one of their most active components. TsEVs have been shown to induce a stable tolerogenic phenotype of human monocyte-derived dendritic cells (hDC), which are then able to induce regulatory T cells (Treg). It has also been shown that TsEVs can alleviate allergic airway inflammation in a mouse model. However, themechanisms of action TsEVs underlying the observed effects are still unknown. Therefore, the aim of this study was to investigate how TsEVs interact with human cells and whichsignalling pathways they employ. </ns1:description>
    <ns1:keyword language="en">Trichinella spiralis, extracellular vesicles, ES L1</ns1:keyword>
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      <ns2:identifier>978-86-905626-1-9</ns2:identifier>
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      <ns2:identifier>https://srbevs.rs/2nd-move-symposium/</ns2:identifier>
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    <ns1:upload_date>2025-04-08T11:24:50.367Z</ns1:upload_date>
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        <ns3:firstname>Sofija</ns3:firstname>
        <ns3:lastname>Glamočlija</ns3:lastname>
        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia</ns3:institution>
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        <ns3:firstname>Anna</ns3:firstname>
        <ns3:lastname>Schmid</ns3:lastname>
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        <ns3:firstname>Alisa</ns3:firstname>
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        <ns3:lastname>Djokić</ns3:lastname>
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        <ns3:firstname>Maja</ns3:firstname>
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    <ns12:name_magazine language="en">2nd MOVE Symposium-Abstract book</ns12:name_magazine>
    <ns12:publisher>Serbian Society for Extracellular Vesicles, SrbEVs with Austrian Society for Extracellular Vesicles, ASEV Baltic Society for Extracellular Vesicles, BSEV Italian Society for Extracellular Vesicles, EVIta French Society for Extracellular Vesicles, FSEV Spanish Society for Extracellular Vesicles, GEIVEX German Society for Extracellular Vesicles, GSEV United Kingdom Society for Extracellular Vesicles, UKEV</ns12:publisher>
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