
<ns0:uwmetadata xmlns:ns0="http://phaidra.univie.ac.at/XML/metadata/V1.0" xmlns:ns1="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0" xmlns:ns10="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0" xmlns:ns11="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0/entity" xmlns:ns12="http://phaidra.univie.ac.at/XML/metadata/digitalbook/V1.0" xmlns:ns13="http://phaidra.univie.ac.at/XML/metadata/etheses/V1.0" xmlns:ns2="http://phaidra.univie.ac.at/XML/metadata/extended/V1.0" xmlns:ns3="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/entity" xmlns:ns4="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/requirement" xmlns:ns5="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/educational" xmlns:ns6="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/annotation" xmlns:ns7="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/classification" xmlns:ns8="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/organization" xmlns:ns9="http://phaidra.univie.ac.at/XML/metadata/histkult/V1.0">
  <ns1:general>
    <ns1:identifier>o:36057</ns1:identifier>
    <ns1:title language="en">Collagen Hydrogel Embedded SHED-EVs for Enhanced Osteogenesis</ns1:title>
    <ns1:language>en</ns1:language>
    <ns1:description language="en">ABSTRACT
Introduction: Mesenchymal stem/stromal cells (MSCs) from the dental pulp of human exfoliated deciduous teeth (SHED cells) have shown promising results in bone tissue regeneration. The application of SHED-derived extracellular vesicles (EVs) to bone defects can be achieved using biomaterial scaffolds. Collagen scaffolds, which are natural polymers with slow degradation times, are particularly suitable for EVs entrapment. This study aimed to examine the release rate of embedded SHED-EVs from collagen scaffolds and to evaluate their osteogenic capacity when combined with collagen and gradually released. Methods: SHED-EVs were isolated using differential ultracentrifugation and characterized using nanotracking particle analysis (NTA), Western Blot (WB), and scanning electron microscopy (SEM). </ns1:description>
    <ns1:keyword language="en">Mesenchymal stem/stromal cells (MSCs), SHED-derived extracellular vesicles (EVs)</ns1:keyword>
    <ns2:identifiers>
      <ns2:resource>1552100</ns2:resource>
      <ns2:identifier>978-86-905626-1-9</ns2:identifier>
    </ns2:identifiers>
    <ns2:identifiers>
      <ns2:resource>1552102</ns2:resource>
      <ns2:identifier>https://srbevs.rs/2nd-move-symposium/</ns2:identifier>
    </ns2:identifiers>
  </ns1:general>
  <ns1:lifecycle>
    <ns1:upload_date>2025-04-01T09:00:37.023Z</ns1:upload_date>
    <ns1:status>44</ns1:status>
    <ns2:peer_reviewed>yes</ns2:peer_reviewed>
    <ns1:contribute seq="0">
      <ns1:role>46</ns1:role>
      <ns1:entity seq="0">
        <ns3:firstname>Marija </ns3:firstname>
        <ns3:lastname>Milivojević</ns3:lastname>
        <ns3:institution>Inovation Center of The Faculty of Technology and Metallurgy, Belgrade, Serbia</ns3:institution>
      </ns1:entity>
      <ns1:entity seq="5">
        <ns3:firstname>Maja</ns3:firstname>
        <ns3:lastname>Kosanović</ns3:lastname>
        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia</ns3:institution>
        <ns3:title1>doktor bioloških nauka</ns3:title1>
        <ns3:type>person</ns3:type>
        <ns3:orcid>0000-0002-1143-1805</ns3:orcid>
      </ns1:entity>
      <ns1:entity seq="4">
        <ns3:firstname>Sergej</ns3:firstname>
        <ns3:lastname>Tomić</ns3:lastname>
        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia</ns3:institution>
        <ns3:title1>doktor bioloških nauka</ns3:title1>
        <ns3:type>person</ns3:type>
        <ns3:orcid>0000-0003-2570-1295</ns3:orcid>
      </ns1:entity>
      <ns1:entity seq="3">
        <ns3:firstname>Marina</ns3:firstname>
        <ns3:lastname>Bekić</ns3:lastname>
        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia</ns3:institution>
        <ns3:type>person</ns3:type>
        <ns3:orcid>0000-0002-6945-4241</ns3:orcid>
      </ns1:entity>
      <ns1:entity seq="2">
        <ns3:firstname>Miodrag</ns3:firstname>
        <ns3:lastname>Čolić</ns3:lastname>
        <ns3:institution>Serbian Academy of Sciences, Belgrade, Serbia</ns3:institution>
        <ns3:type>person</ns3:type>
      </ns1:entity>
      <ns1:entity seq="1">
        <ns3:firstname>Djordje</ns3:firstname>
        <ns3:lastname>Janaćković</ns3:lastname>
        <ns3:institution>Faculty of Technology and Metallurgy, Belgrade, Serbia</ns3:institution>
        <ns3:type>person</ns3:type>
      </ns1:entity>
    </ns1:contribute>
  </ns1:lifecycle>
  <ns1:technical>
    <ns1:format>application/pdf</ns1:format>
    <ns1:size>1607790</ns1:size>
    <ns1:location>https://phaidrabg.bg.ac.rs/o:36057</ns1:location>
  </ns1:technical>
  <ns1:rights>
    <ns1:cost>no</ns1:cost>
    <ns1:copyright>yes</ns1:copyright>
    <ns1:license>1</ns1:license>
  </ns1:rights>
  <ns1:classification>
    <ns1:purpose>70</ns1:purpose>
  </ns1:classification>
  <ns1:organization>
    <ns8:hoschtyp>92000004</ns8:hoschtyp>
    <ns8:orgassignment>
      <ns8:faculty>11A41</ns8:faculty>
    </ns8:orgassignment>
    <ns8:orgassignment>
      <ns8:faculty>11A29</ns8:faculty>
      <ns8:department>11A2904</ns8:department>
    </ns8:orgassignment>
  </ns1:organization>
  <ns12:digitalbook>
    <ns12:name_magazine language="en">2nd MOVE Symposium Abstract book, 8-11 October 2024, Belgrade, Serbia</ns12:name_magazine>
    <ns12:publisher>Serbian Society for Extracellular Vesicles, SrbEVs with Austrian Society for Extracellular Vesicles, ASEV Baltic Society for Extracellular Vesicles, BSEV Italian Society for Extracellular Vesicles, EVIta French Society for Extracellular Vesicles, FSEV Spanish Society for Extracellular Vesicles, GEIVEX German Society for Extracellular Vesicles, GSEV United Kingdom Society for Extracellular Vesicles, UKEV</ns12:publisher>
    <ns12:releaseyear>2024</ns12:releaseyear>
  </ns12:digitalbook>
</ns0:uwmetadata>