o:36034 Do extracellular vesicles from Trichinella spiralis muscle larvae harbor the potential to induce regulatory T cells? en ABSTRACT During the chronic phase of the infection, Trichinella spiralis, through its excretory-secretory products (ES L1), induce Th2 and regulatory immune responses, thus creating nonpermissive environment for the development of autoimmune and other chronic inflammatory diseases. Our major goal is to discover immunomodulatory components within ES L1 products, so that we can characterize them and use them to design treatment for humans. Extracellular vesicles, isolated from T. spiralis ES L1 products (TsEVs), may be the important players in initiation, progression and regulation of the immune response, via their impact on dendritic cells. Human monocyte derived dendritic cells (DCs) were treated with TsEVs and subsequently co-cultivated with allogenic T cells. Trichinella spiralis, extracellular vesicles, regulatory T cells 1552100 978-86-918341-1-1 2025-03-21T10:13:31.880Z 44 yes 46 Sofija Glamočlija University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia 0000-0003-0497-5852 Nataša Ilić Institute for Biological Research "Sinisa Stankovic", National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia person 0000-0001-6738-7033 Alisa Gruden-Movsesijan University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-3061-5474 Ljiljana Sabljić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person 0000-0001-6027-591X Sergej Tomić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0003-2570-1295 Ljiljana Sofronić-Milosavljević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person 0000-0002-2721-125X Maja Kosanović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-1143-1805 application/pdf 749923 https://phaidrabg.bg.ac.rs/o:36034 no yes 1 70 92000004 11A29 11A2904 11A21 Program and Abstract Book-16th International Conference on Trichinellosis, Belgrade, Serbia, 2023 Institute for the Application of Nuclear Energy INEP 2023