o:36032 Can we use Trichinella spiralis muscle larvae extracellular vesicles for the treatment of allergic airway inflammation? en ABSTRACT Extracelular vesicles (EVs) are a fundamental way of communication between cells of one organism but also between different organisms and even different species. These nano-sized membrane-limited biological particles, carry information in the form of proteins, lipids, RNA, as well as other molecules, and deliver them to target cells, thus playing role in all physiological and pathophysiological processes in an organism. We have recently discovered that extracellular vesicles isolated from Trichinella spiralis excretory-secretory products (TsEVs) exert immunomodulatory properties on human monocyte derived dendritic cells. It was previously shown that T. spiralis infection alters immune response and exerts beneficial effect in mice with allergic airway inflammation. Our goal was to investigate the potential of TsEVs to ameliorate ovalbumin (OVA)-induced allergy in a murine model. Experimental allergic airway inflammation was induced in BALB/c mice by intraperitoneal injection of OVA in alum. On days 21-24 mice were challenged with intranasal application of OVA. Trichinella spiralis, extracellular vesicles, allergy 1552100 978-86-918341-1-1 1552102 https://www.ict-16.com/programme-at-a-glance/ 91552100 COBISS.SR-ID 123197193 2025-03-20T13:36:25.000Z 44 yes 46 Sofija Glamočlija University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia 0000-0003-0497-5852 Maja Kosanović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-1143-1805 Irma Schabussova Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria person Saša Vasilev University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor medicinskih nauka-veterina person 0000-0001-7870-2713 Ljiljana Sabljić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person 0000-0001-6027-591X Alisa Gruden-Movsesijan University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-3061-5474 Nataša Ilić Institute for Biological Research "Sinisa Stankovic", National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia person 0000-0001-6738-7033 Anna Schmid Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria person application/pdf 763882 https://phaidrabg.bg.ac.rs/o:36032 no yes 1 70 92000004 11A29 11A2904 11A21 Program and Abstract Book-16th International Conference on Trichinellosis, Belgrade, Serbia, 2023 Institute for the application of nuclear energy, INEP 2023