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    <ns1:identifier>o:35967</ns1:identifier>
    <ns1:title language="en">Immunomodulation by extracellular vesicles from Trichinella spiralis muscle larvae: increasing tolerogenic properties of human dendritic cells</ns1:title>
    <ns1:language>en</ns1:language>
    <ns1:description language="en">ABSTRACT
Excretory-secretory products (ES) of parasitic worms (helminths) shift hosts’ immunological balance toward
Th2 and regulatory responses thus acting beneficial in chronic inflammations, i.e. autoimmune diseases. As shown in several
helminths, extracellular vesicles (EVs) are active immunomodulatory component of ES.We found that Trichinella spiralis produces EVs (TsEVs) which influence cytokine production by PBMC. Now we aim to show how TsEVs influence human dendritic
cells (DC), as key players in initiation, progression and regulation of immune response.</ns1:description>
    <ns1:keyword language="en">TsEVs, autoimmune diseases, extracellular vesicles, Trichinella spiralis</ns1:keyword>
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      <ns2:identifier>10.1002/jev2.12083</ns2:identifier>
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    <ns2:identifiers>
      <ns2:resource>1552101</ns2:resource>
      <ns2:identifier>2001-3078</ns2:identifier>
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        <ns3:firstname>Sofija</ns3:firstname>
        <ns3:lastname>Glamočlija</ns3:lastname>
        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia</ns3:institution>
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        <ns3:firstname>Maja</ns3:firstname>
        <ns3:lastname>Kosanović</ns3:lastname>
        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia</ns3:institution>
        <ns3:title1>doktor bioloških nauka</ns3:title1>
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        <ns3:lastname>Sofronić-Milosavljević</ns3:lastname>
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        <ns3:firstname>Sergej</ns3:firstname>
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        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia</ns3:institution>
        <ns3:title1>doktor bioloških nauka</ns3:title1>
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        <ns3:lastname>Sabljić</ns3:lastname>
        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia</ns3:institution>
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        <ns3:orcid>0000-0001-6027-591X</ns3:orcid>
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        <ns3:firstname>Alisa</ns3:firstname>
        <ns3:lastname>Gruden-Movsesijan</ns3:lastname>
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        <ns3:title1>doktor bioloških nauka</ns3:title1>
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        <ns3:firstname>Nataša</ns3:firstname>
        <ns3:lastname>Ilić</ns3:lastname>
        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia</ns3:institution>
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  <ns12:digitalbook>
    <ns12:name_magazine language="en">Journal of extracellular vesicles/ISEV2021 Annual Meeting, May 18-21, 2021, Virtual meeting-ISEV2021 Abstract Book </ns12:name_magazine>
    <ns12:volume>10 (Suppl 1)</ns12:volume>
    <ns12:publisher>Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles</ns12:publisher>
    <ns12:releaseyear>2021</ns12:releaseyear>
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