o:35965 How Trichinella spiralis-derived extracellular vesicles affect dendritic cells en ABSTRACT Trichinella spiralis is a very promising candidate for modulation of immune response in sense of biasing the inflammatory towards anti-inflammatory type of response. This effect is achieved via its excretory secretory muscle larvae (ES L1) antigens which affect the maturation status and function of dendritic cells (DCs) as the most potent antigen presenting cells. ES L1 induces the tolerogenic status of DCs which leads to the mitigation of Th1 type of response and the activation of regulatory type of immune response both in vitro and in vivo. ES L1 treated DCs successfully alleviated the severity of experimental autoimmune encephalomyelitis, the animal model of human disease multiple sclerosis. Trichinella spiralis, ES L1, TsEVs 2025-02-24T20:52:56.160Z 44 yes 46 Nataša Ilić Institute for Biological Research "Siniša Stanković", National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia Maja Kosanović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia doktor bioloških nauka person 0000-0002-1143-1805 Alisa Gruden-Movsesijan University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia doktor bioloških nauka person 0000-0002-3061-5474 Sergej Tomić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia doktor bioloških nauka person 0000-0003-2570-1295 Sofija Glamočlija University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia person 0000-0003-0497-5852 Marina Bekić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia person 0000-0002-6945-4241 Ljiljana Sofronić-Milosavljević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Belgrade, Serbia person application/pdf 8116137 https://phaidrabg.bg.ac.rs/o:35965 no yes 1 70 92000004 11A29 11A2904 13th European Multicolloquium of Parasitology, 12-16 October 2021, Belgrade, Serbia 27 2021