info:eu-repo/semantics/conferenceProceedings ABSTRACT Trichinella spiralis is a very promising candidate for modulation of immune response in sense of biasing the inflammatory towards anti-inflammatory type of response. This effect is achieved via its excretory secretory muscle larvae (ES L1) antigens which affect the maturation status and function of dendritic cells (DCs) as the most potent antigen presenting cells. ES L1 induces the tolerogenic status of DCs which leads to the mitigation of Th1 type of response and the activation of regulatory type of immune response both in vitro and in vivo. ES L1 treated DCs successfully alleviated the severity of experimental autoimmune encephalomyelitis, the animal model of human disease multiple sclerosis. application/pdf 8116137 bytes 2021 Ilić, Nataša Kosanović, Maja Gruden-Movsesijan, Alisa Tomić, Sergej Glamočlija, Sofija Bekić, Marina Sofronić-Milosavljević, Ljiljana All rights reserved eng https://phaidrabg.bg.ac.rs/o:35965 Trichinella spiralis, ES L1, TsEVs 13th European Multicolloquium of Parasitology, 12-16 October 2021, Belgrade, Serbia startpage: 27 How Trichinella spiralis-derived extracellular vesicles affect dendritic cells