o:35949 Caffeic acid stimulates migration and invasion of human trophoblast HTR-8/SVneo cells Kafeinska kiselina stimuliše migraciju i invaziju trofoblastnih HTR-8/SVneo ćelija čoveka en ABSTRACT The placenta is a transient organ essential for development of the fetus. Adequate invasion of trophoblast cells, specialized cells of the placenta, is of utmost importance for the establishment and maintenance of healthy pregnancy. Caffeic acid (CA), one of the most abundantly present hydroxycynamic acids in everyday human diet, exhibits various physiological effects such as antioxidant, anti-inflammatory and anticancer activities including an inhibitory effect on migration and invasion of different cancer cell types. There are not many studies on CA safety in human pregnancy. Therefore, the aim of this research was to investigate the potential of CA to affect trophoblast cell function. We evaluated adhesion, migration and invasion of human trophoblast HTR-8/SVneo cells following CA treatment by functional assays. Caffeic acid; extravillous trophoblast cells; cell migration; invasion 1552099 10.1039/D4FO03699A 2025-02-20T08:17:28.992Z 44 yes 46 Aleksandra Vilotić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka 0000-0002-0898-5401 Sanja Kostić Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Serbia person Andrea Pirković University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-1182-4895 Žanka Bojić-Trbojević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-5619-1027 Dragana Dekanski University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor medicinskih nauka person 0000-0001-8467-4165 Svetlana Vrzić-Petronijević Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Serbia person Milica Jovanović Krivokuća University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-8292-4853 application/pdf 98352 https://phaidrabg.bg.ac.rs/o:35949 no yes 1 70 92000001 11A29 11A2901 11A32 11A3260 Food and Function 16 4 1603 1614 The Royal Society of Chemistry 2025