o:35902 Bioactivity Assessment of Functionalized TiO2 Powder with Dihydroquercetin en ABSTRACT Biological activities, including cell viability, oxidative stress, genotoxicity/antigenotoxicity, and antimicrobial activity, were evaluated for a visible-light-responsive TiO2-based ICT complex with dihydroquercetin (DHQ) and compared with pristine TiO2, its inorganic component. Pristine TiO2 did not induce cytotoxicity in MRC-5 or HeLa cells within the tested concentration range (1–20 mg/mL), while TiO2/DHQ displayed a significant reduction in cell viability in both cell lines at higher concentrations (≥10 mg/mL). The analysis of reactive oxygen species (ROS) production revealed that TiO2/DHQ significantly reduced ROS levels in both cell types (MRC-5 and HeLa), with HeLa cells showing a more substantial reduction at lower concentrations. TiO2; dihydroquercetin; interfacial charge transfer complex; cytotoxicity; antigenotoxicity; antimicrobial activity 1552099 10.3390/ijms26041475 2025-02-13T13:40:35.887Z 44 yes 46 Valentina Nikšić VINČA Institute of Nuclear Sciences—National Institute of the Republic of Serbia, Centre of Excellence for Photoconversion, University of Belgrade, Belgrade, Serbia Andrea Pirković University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-1182-4895 Biljana Spremo-Potparević Department of Pathobiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia person Lada Živković Department of Pathobiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia person Dijana Topalović Department of Pathobiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia person Jovan M. Nedeljković VINČA Institute of Nuclear Sciences—National Institute of the Republic of Serbia, Centre of Excellence for Photoconversion, University of Belgrade, Belgrade, Serbia person Vesna Lazić VINČA Institute of Nuclear Sciences—National Institute of the Republic of Serbia, Centre of Excellence for Photoconversion, University of Belgrade, Belgrade, Serbia person application/pdf 2282711 https://phaidrabg.bg.ac.rs/o:35902 no yes 16 70 92000001 11A28 11A29 11A2901 11A13 International Journal of Molecular Sciences 26 4 1475 MDPI, Basel, Switzerland 2025