info:eu-repo/semantics/article TiO2; dihydroquercetin; interfacial charge transfer complex; cytotoxicity; antigenotoxicity; antimicrobial activity https://phaidrabg.bg.ac.rs/o:35902 doi:10.3390/ijms26041475 application/pdf 2282711 bytes MDPI, Basel, Switzerland 2025 ABSTRACT Biological activities, including cell viability, oxidative stress, genotoxicity/antigenotoxicity, and antimicrobial activity, were evaluated for a visible-light-responsive TiO2-based ICT complex with dihydroquercetin (DHQ) and compared with pristine TiO2, its inorganic component. Pristine TiO2 did not induce cytotoxicity in MRC-5 or HeLa cells within the tested concentration range (1–20 mg/mL), while TiO2/DHQ displayed a significant reduction in cell viability in both cell lines at higher concentrations (≥10 mg/mL). The analysis of reactive oxygen species (ROS) production revealed that TiO2/DHQ significantly reduced ROS levels in both cell types (MRC-5 and HeLa), with HeLa cells showing a more substantial reduction at lower concentrations. eng Bioactivity Assessment of Functionalized TiO2 Powder with Dihydroquercetin International Journal of Molecular Sciences volume: 26 number: 4 startpage: 1475 http://creativecommons.org/licenses/by/4.0/legalcode Nikšić, Valentina Pirković, Andrea Spremo-Potparević, Biljana Živković, Lada Topalović, Dijana Nedeljković, Jovan M. Lazić, Vesna