o:35898 Glycans in health and disease Glikani u zdravlju i bolesti en ABSTRACT If a cell would produce one protein for each biological function, there would probably be a million of them. Still, the actual number is much lower. To save energy, cells use different methods to modify proteins, thus repurposing them and enabling them to perform different functions. The most common modification is glycosylation, a process in which one or more (the same or different) monosaccharide units are enzymatically linked to a protein (or another biomolecule). Glycan synthesis is complex and incompletely understood process in which different forms of various types of glycans are formed. A set of glycans present in one cell or an organism represents their glycome and is a reflection of cellular condition in a specific environment. Glycome is a very flexible entity that constantly changes even under physiological circumstances, thus reflecting habits of an organism as well as the process of biological ageing. It is, however, more interesting how glycome changes under specific and pathological conditions. Understanding how and why it changes will help treating and reverting some pathological processes. carbohydrate, glycosylation, monosaccharide, N-glycan 1552099 10.5281/zenodo.14535657 1552101 2334-6590 2025-02-13T11:25:36.201Z 44 yes 46 Dragana Robajac University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka 0000-0002-6423-4645 application/pdf 1616420 https://phaidrabg.bg.ac.rs/o:35898 no yes 1 70 92000002 11A29 11A2905 Biologia Serbica 46 2 28 36 Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Serbia 2024