
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/">
  <dc:description xml:lang="eng">ABSTRACT
Thyroglobulin (Tg) is a reliable marker for detecting recurrence in differentiated thyroid cancer (DTC) patients, but frequently occurring Tg antibodies (TgAbs) can hinder accurate measurement. We aimed to develop a preanalytical protocol for precise Tg detection in TgAb presence using the immunoradiometric assay (IRMA) platform. This study involved forty-five patients who underwent IRMA Tg and radioimmunoassay (RIA) TgAb measurements, including two patients monitored for recurrence and one with confirmed recurrence. All three had undetectable Tg levels. We evaluated three preanalytical methods in aiming to separate Tg from TgAbs: buffer only (Protocol 1), micro-spin filters only (Protocol 2), and a combination of both (Protocol 3). </dc:description>
  <dc:date>2024</dc:date>
  <dc:title xml:lang="eng">Advancing Immunoassay Precision: A Novel Preanalytical Method for Enhancing Thyroglobulin Measurement in the Presence of Tg Antibodies</dc:title>
  <dc:rights>http://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:publisher>MDPI, Basel, Switzerland</dc:publisher>
  <dc:subject xml:lang="eng">Tg; Tg immunoassays; IRMA; preanalytical treatment; TgAb interference; DTC follow-up; recurrent DTC</dc:subject>
  <dc:creator id="https://orcid.org/0000-0001-5322-4559">Djorić, Ilona</dc:creator>
  <dc:creator id="https://orcid.org/0000-0003-2225-8988">Todorović, Aleksandra</dc:creator>
  <dc:creator id="https://orcid.org/0000-0001-8233-1636">Gnjatović, Marija</dc:creator>
  <dc:creator id="https://orcid.org/0000-0002-4551-4342">Golubović, Snežana</dc:creator>
  <dc:creator>Žarković, Miloš</dc:creator>
  <dc:creator id="https://orcid.org/0000-0002-2589-3306">Janković Miljuš, Jelena</dc:creator>
  <dc:creator id="https://orcid.org/0000-0001-8475-2266">Išić Denčić, Tijana</dc:creator>
  <dc:creator id="https://orcid.org/0000-0002-2898-6671">Šelemetjev, Sonja</dc:creator>
  <dc:format>application/pdf</dc:format>
  <dc:format>1311455 bytes</dc:format>
  <dc:source>International Journal of Molecular Sciences</dc:source>
  <dc:source>volume: 25</dc:source>
  <dc:source>number: 24</dc:source>
  <dc:identifier>https://phaidrabg.bg.ac.rs/o:35361</dc:identifier>
  <dc:identifier>doi:10.3390/ijms252413252</dc:identifier>
  <dc:language>eng</dc:language>
</oai_dc:dc>