o:35355 LncRNAs Involved in Antioxidant Response Regulation as Biomarkers of Gestational Diabetes: A Study on H19, MALAT1 and MEG3 Duge nekodirajuće RNK uključene u regulaciju antioksidativnog odgovora kao biomarkeri gestacijskog dijabetesa: studija o H19, MALAT1 i MEG3 en ABSTRACT Recent findings highlighted the potential of long non-coding RNAs (lncRNAs) as novel indicators of gestational diabetes mellitus (GDM), as they demonstrate altered expression in metabolic disorders, oxidative stress (OS) and inflammation (IFM). The aim of this study was to evaluate the diagnostic potential and prognostic significance of the OS/IFM-related lncRNAs H19, MALAT1 and MEG3 in GDM and their correlations with redox status-related parameters. The relative quantification of selected lncRNAs from peripheral blood mononuclear cells (PBMCs) of GDM patients and controls (n= 50 each) was performed by qPCR. H19; MALAT1; MEG3; oxidative stress; redox status; inflammation; gestational diabetes; zinc; glutathione reductase; thiol content 1552099 10.3390/antiox13121503 2024-12-12T10:55:33.087Z 44 yes 46 Jovana Stevanović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia 0000-0002-3619-8472 Uroš Petrović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person Ana Penezić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-2539-4507 Ognjen Radojičić University Clinic for Gynecology and Obstetrics "Narodni Front", Belgrade, Serbia person Daniela Ardalić University Clinic for Gynecology and Obstetrics "Narodni Front", Belgrade, Serbia person Milica Mandić University Clinic for Gynecology and Obstetrics "Narodni Front", Belgrade, Serbia person Vesna Mandić-Marković Medical School, University of Belgrade, Belgrade, Serbia person Željko Miković University Clinic for Gynecology and Obstetrics "Narodni Front", Belgrade, Serbia person Miloš Brkušanin Centre for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia person Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-2042-0056 Zorana Dobrijević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-4652-7719 application/pdf 2400707 https://phaidrabg.bg.ac.rs/o:35355 no yes 16 70 92000001 11A29 11A2905 11A32 11A02 Antioxidants 13 12 1503 MDPI, Basel, Switzerland 2024