
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/">
  <dc:format>application/pdf</dc:format>
  <dc:format>1353393 bytes</dc:format>
  <dc:creator>Popović, Petar</dc:creator>
  <dc:creator id="https://orcid.org/0000-0002-1182-4895">Pirković, Andrea</dc:creator>
  <dc:creator>Topalović, Dijana</dc:creator>
  <dc:creator>Živković, Lada</dc:creator>
  <dc:creator>Marković, Milica</dc:creator>
  <dc:creator>Spremo-Potparević, Biljana</dc:creator>
  <dc:language>eng</dc:language>
  <dc:title xml:lang="eng">Cytotoxic, Antioxidant, and Anti-Genotoxic Properties of Combretastatin A4 in Human Peripheral Blood Mononuclear Cells: A Comprehensive In Vitro Study</dc:title>
  <dc:rights>http://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:publisher>MDPI, Basel, Switzerland</dc:publisher>
  <dc:source>Biomolecules</dc:source>
  <dc:source>volume: 14</dc:source>
  <dc:source>startpage: 1535</dc:source>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:subject xml:lang="eng">combretastatin A4; PBMC; oxidative stress; genotoxicity; trophoblast</dc:subject>
  <dc:date>2024</dc:date>
  <dc:description xml:lang="eng">ABSTRACT
Despite significant advances in drug discovery and the promising antitumor potential of
combretastatin A4 (CA-4), which selectively targets rapidly dividing cancer cells, CA-4’s effects on non-dividing human cells, such as peripheral blood mononuclear cells (PBMCs), remain unclear. The aim of this study is to evaluate the in vitro bioactivity of CA-4 in human PBMCs, focusing on its antigenotoxic and antioxidant properties, while comparing its cytotoxic potency against PBMCs, cancer cell lines (JAR and HeLa), and the normal trophoblast cell line HTR 8/SVneo. Cell viability and metabolic activity were evaluated using the MTT assay.</dc:description>
  <dc:identifier>https://phaidrabg.bg.ac.rs/o:35281</dc:identifier>
  <dc:identifier>doi:10.3390/biom14121535</dc:identifier>
</oai_dc:dc>