o:35262 DESIGN AND EVALUATION OF LIPOSOMAL FORMULATION OF CAROB (Ceratonia siliqua L.) PULP EXTRACT en The carob (Cerationa siliqua L.) pulp flour is used primarily in the food industry. As a valuable source of bioactive compounds (polyphenols), it is a good candidate for pharmaceutical formulation research and development. In this study, carob pulp extract-loaded liposomal particles were developed using the proliposome procedure and characterized via encapsulation efficiency (EE), vesicle size, polydispersity index (PDI), zeta potential, mobility, and viscosity. The obtained results suggest that the EE is high (80.6±3.3%). The particle size and PDI results indicated the existence of the multilamellar and uniform liposomal system. Lower values of zeta potential and mobility (-17.8±1.0 mV and -1.40±0.08 µmcm/Vs, respectively) of developed liposomes suggest that future experiments should be focused on the carob pulp liposomal nutraceutical formulation improvement, particularly its stability. 1552099 10.46793/8FDSQ.PA2DD 1552100 978-86-7306-173-3 2024-11-29T20:36:47.807Z 44 yes 46 Dragana Dekanski Institute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia doktor medicinskih nauka 0000-0001-8467-4165 Aleksandar Rašković Department of Pharmacology, Toxicology, and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia person Nikola Martić Department of Pharmacology, Toxicology, and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia person Andrea Pirković Institute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia doktor bioloških nauka person 0000-0002-1182-4895 Aleksandra Jovanović Institute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia doktor tehnoloških nauka person 0000-0001-5394-0125 application/pdf 481568 https://phaidrabg.bg.ac.rs/o:35262 no yes 19 70 92000004 11A29 DESIGN AND EVALUATION OF LIPOSOMAL FORMULATION OF CAROB (Ceratonia siliqua L.) PULP EXTRACT 21 24 8 th Workshop FOOD AND DRUG SAFETY AND QUALITY September 26 th, 2024, PROCEEDINGS Vinča Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Republic of Serbia 2024