Introduction: The peel of pomegranate (Punica granatum L., Punicaceae) fruit is usually treated as a waste. On the other hand, it is a rich source of polyphenols, including phenolic acids, flavonoids, and tannins. A broad range of biological activities was reported for pomegranate peel extracts. Material and Methods: Extract of pomegranate peel (PPE) was obtained by double percolation using 50% EtOH and spray dried. HPLC was applied for the chemical analysis of the most abundant phenolics. PPE and individual compounds were tested using in vitro inhibition of hyaluronidase, elastase, collagenase, and tyrosinase. In vitro anti-inflammatory potential of PPE was investigated in the erythrocyte membrane stabilization assay. Results: The most abundant compounds in PPE was punicalagin, followed by punicalin, ellagic and gallic acid. PPE showed IC50 values of 534.76 µg/ml for hyaluronidase, 651.81 µg/ml for elastase, 1013.81 µg/ml for collagenase, and 537.60 µg/ml for tyrosinase inhibition. The most active individual compound was ellagic acid, except for collagenase inhibition assay where punicalin was the strongest inhibitor (IC50 value of 95.63 µg/ml). Also, PP extract showed promising concentration-dependent in vitro anti-inflammatory activity. Conclusion: Both, PPE and individual compounds showed promising skin beneficial effects to meet trends in cosmetic and healthcare sector http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode University of Milan eng Skin beneficial effects of pomegranate peel extract and its dominant compounds Skin beneficial effects of pomegranate peel extract and its dominant compounds info:eu-repo/semantics/abstract application/pdf 677364 bytes https://phaidrabg.bg.ac.rs/o:35261 doi:10.60738/03ak-mn82 2024 Šavikin, Katarina Alimpić Aradski, Ana Jovanović, Aleksandra Ćujić Nikolić, Nada Živković, Jelena