o:34914 miR-146a-5p and miR-21-5p from extracellular vesicles as potential biomarkers in gestational diabetes miR-146a-5p i miR-21-5p iz ekstraćelijskih vezikula kao potencijalni biomarkeri gestacijskog dijabetesa en ABSTRACT Introduction: The importance of dysregulation of the anti-oxidative system as the driving force of severe damage and pregnancy complications in gestational diabetes (GDM) is well supported by numerous lines of evidence. MicroRNA-based regulatory mechanism demonstrate impairment associated with GDM, as well as disturbances related to the presence of (glyco)oxidative stress ((g)OS) interconnected with inflammation (IFM). Therefore, we hypothesized that microRNAs may act as potential sensors and/or effectors of (g)OS/IFM in GDM and we selected known (g)OS/IFM-associated microRNAs mir-146a-5p and miR-21-5p as candidates for GDM biomarker analysis. The aim was to assess the biomarker potential of these microRNAs from serum-derived extracellular vesicles (EVs). miR-146a-5p, miR-21-5p, extracellular vesicles, oxidative stress, inflammation 1552100 978-86-905626-1-9 2024-10-17T12:27:40.720Z 44 yes 46 Jovana Stevanović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia 0000-0002-3619-8472 Ognjen Radojičić Gynecology and Obstetrics Clinic "Narodni front", Belgrade, Serbia person Ninoslav Mitić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0003-2756-6517 Ana Penezić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-2539-4507 Dragana Robajac University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-6423-4645 Miloš Šunderić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-0940-9481 Goran Miljuš University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0001-6417-8711 Danilo Četić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person 0000-0001-9705-3237 Milica Mandić Gynecology and Obstetrics Clinic "Narodni front", Belgrade, Serbia person Daniela Ardalić Gynecology and Obstetrics Clinic "Narodni front", Belgrade, Serbia person Vesna Mandić Marković School of Medicine, University of Belgrade, Belgrade, Serbia person Željko Miković School of Medicine, University of Belgrade, Belgrade, Serbia person Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-2042-0056 Zorana Dobrijević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-4652-7719 application/pdf 2933196 https://phaidrabg.bg.ac.rs/o:34914 no yes 18 70 92000004 11A29 11A2905 11A29 11A2903 11A32 2nd MOVE Symposium-Abstract Book Serbian Society for Extracellular Vesicles, SrbEVs with Austrian Society for Extracellular Vesicles, ASEV Baltic Society for Extracellular Vesicles, BSEV Italian Society for Extracellular Vesicles, EVIta French Society for Extracellular Vesicles, FSEV Spanish Society for Extracellular Vesicles, GEIVEX German Society for Extracellular Vesicles, GSEV United Kingdom Society for Extracellular Vesicles, UKEV 2024