2nd MOVE Symposium-Abstract Book http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode miR-146a-5p and miR-21-5p from extracellular vesicles as potential biomarkers in gestational diabetes info:eu-repo/semantics/conferenceProceedings miR-146a-5p, miR-21-5p, extracellular vesicles, oxidative stress, inflammation ABSTRACT Introduction: The importance of dysregulation of the anti-oxidative system as the driving force of severe damage and pregnancy complications in gestational diabetes (GDM) is well supported by numerous lines of evidence. MicroRNA-based regulatory mechanism demonstrate impairment associated with GDM, as well as disturbances related to the presence of (glyco)oxidative stress ((g)OS) interconnected with inflammation (IFM). Therefore, we hypothesized that microRNAs may act as potential sensors and/or effectors of (g)OS/IFM in GDM and we selected known (g)OS/IFM-associated microRNAs mir-146a-5p and miR-21-5p as candidates for GDM biomarker analysis. The aim was to assess the biomarker potential of these microRNAs from serum-derived extracellular vesicles (EVs). 2024 eng application/pdf 2933196 bytes Serbian Society for Extracellular Vesicles, SrbEVs with Austrian Society for Extracellular Vesicles, ASEV Baltic Society for Extracellular Vesicles, BSEV Italian Society for Extracellular Vesicles, EVIta French Society for Extracellular Vesicles, FSEV Spanish Society for Extracellular Vesicles, GEIVEX German Society for Extracellular Vesicles, GSEV United Kingdom Society for Extracellular Vesicles, UKEV Stevanović, Jovana Radojičić, Ognjen Mitić, Ninoslav Penezić, Ana Robajac, Dragana Šunderić, Miloš Miljuš, Goran Četić, Danilo Mandić, Milica Ardalić, Daniela Mandić Marković, Vesna Miković, Željko Nedić, Olgica Dobrijević, Zorana https://phaidrabg.bg.ac.rs/o:34914 ISBN: 978-86-905626-1-9