2024 eng application/pdf 1855316 bytes Stevanović, Jovana Radojičić, Ognjen Penezić, Ana Robajac, Dragana Šunderić, Miloš Miljuš, Goran Četić, Danilo Ardalić, Daniela Mandić, Milica Mandić Marković, Vesna Miković, Željko Nedić, Olgica Dobrijević, Zorana Serbian Biochemical Society https://phaidrabg.bg.ac.rs/o:34910 ISBN: 978-86-7220-141-3 Serbian Biochemical Society, Thirteenth Conference International Scientific Meeting: "Amplifying Biochemistry Concepts" Diagnostic significance of miR-146a, miR-21 and miR-155 from PBMCs in gestational diabetes http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode info:eu-repo/semantics/conferenceProceedings miR-146a-5p, miR-21-5p, mir-155-5p, PBMC, oxidative stress, redox status ABSTRACT MicroRNA-based mechanisms are heavily dysregulated in disorders of glucose metabolism, including gestational diabetes (GDM) and its common successor, type 2 diabetes mellitus. Since oxidative stress (OS) and the interconnected low-level inflammation (IFM) accompany GDM and the associated pregnancy complications, we selected known OS/IFM-related microRNAs as candidates for a study on biomarker properties in GDM. The aim of the conducted research was to evaluate the diagnostic and prognostic significance of miR-146a-5p, miR-155-5p and miR-21-5p from peripheral blood mononuclear cells (PBMCs), as well as their potential as indicators of glucose and lipid status in the second/early third pregnancy trimester.