o:34493 TAXIFOLIN MODULATES mRNA EXPRESSION OF INVASION-ASSOCIATED MARKERS AND STIMULATES MIGRATION OF HUMAN TROPHOBLAST CELLS en ABSTRACT During first trimester of pregnancy, the specific regulation of extravillous trophoblast migration and invasion into the maternal uterine wall is essential for successful placental development. Taxifolin (TAX) is a flavonoid of strong antioxidant activity that recently showed cytoprotective effects in trophoblast cells. The aim was to investigate if TAX can affect cell adhesion and migration in HTR- 8/SVneo extravillous trophoblast cells as well as the expression of molecules that mediate these processes. Concentrations of TAX 10 and 100 μM were selected according to the previously reported cytoprotective effects. taxifolin, trophoblast, integrins, matrix metalloproteinases, cell migration 1552100 978-86-7834-438-1 2024-08-19T06:35:40.098Z 44 yes 46 Aleksandra Vilotić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka 0000-0002-0898-5401 Andrea Pirković University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-1182-4895 Biljana Spremo Potparević University of Belgrade, Faculty of Pharmacy, Serbia person Žanka Bojić-Trbojević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-5619-1027 Marija Bruić University of Belgrade, Faculty of Pharmacy, Serbia person Milica Jovanović Krivokuća University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-8292-4853 application/pdf 299310 https://phaidrabg.bg.ac.rs/o:34493 no yes 18 70 92000004 11A29 11A2901 11A13 UNIFood2024 Conference-Book of Abstract University of Belgrade, Faculty of Agriculture 2024