ABSTRACT During first trimester of pregnancy, the specific regulation of extravillous trophoblast migration and invasion into the maternal uterine wall is essential for successful placental development. Taxifolin (TAX) is a flavonoid of strong antioxidant activity that recently showed cytoprotective effects in trophoblast cells. The aim was to investigate if TAX can affect cell adhesion and migration in HTR- 8/SVneo extravillous trophoblast cells as well as the expression of molecules that mediate these processes. Concentrations of TAX 10 and 100 μM were selected according to the previously reported cytoprotective effects. University of Belgrade, Faculty of Agriculture 2024 info:eu-repo/semantics/conferenceProceedings UNIFood2024 Conference-Book of Abstract http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode Vilotić, Aleksandra Pirković, Andrea Spremo Potparević, Biljana Bojić-Trbojević, Žanka Bruić, Marija Jovanović Krivokuća, Milica https://phaidrabg.bg.ac.rs/o:34493 ISBN: 978-86-7834-438-1 eng application/pdf 299310 bytes taxifolin, trophoblast, integrins, matrix metalloproteinases, cell migration TAXIFOLIN MODULATES mRNA EXPRESSION OF INVASION-ASSOCIATED MARKERS AND STIMULATES MIGRATION OF HUMAN TROPHOBLAST CELLS