o:34254 Encapsulation of Fumaria officinalis extract in the liposomal vesicles en Fumaria officinalis (fumitory) extracts have shown antimicrobial, antioxidative, antispasmodic, laxative, anthelmintic, cholagogue, cytotoxic, and sedative effects. The mentioned health benefits can be attributed to the high content of polyphenol and alkaloid compounds. However, the mentioned compounds possess low solubility, stability, and bioavailability. Therefore, their encapsulation in different carriers is necessary. Liposomes are widely used as carriers for the encapsulation, preservation, and controlled release of numerous hydrophilic and lipophilic bioactive principles from different plant sources. Thus, the aim of the presented study is the development and physicochemical characterization of F. officinalis extract-loaded liposomes in terms of encapsulation efficiency, vesicle size, polydispersity index (PDI), zeta potential, conductivity, and mobility. The extract-loaded liposomes were obtained in the proliposome method using 1 g of phospholipids, 1 mL of fumitory ethanol extract, and 10 mL of ultrapure water. Encapsulation efficiency was indirectly calculated by the polyphenol concentration determined in the supernatant. Particle size, PDI, zeta potential, conductivity, and mobility were measured by photon correlation spectroscopy. The encapsulation efficiency of polyphenols was >73%. The vesicle size and PDI were 274.0±0.7 nm and 0.307±0.020, respectively. The zeta potential, conductivity, and mobility were -6.34±0.16 mV, 0.465 mS/cm, and -0.491±0.011 µmcm/Vs, respectively. The beneficial effects of biologically active compounds from F. officinalis herba on human health, as well as their sensitivity, highlight the application of small, uniform, and stable phospholipid liposomal vesicles as their carrier. encapsulation, fumitory, liposomes, polyphenols 1552100 978-86-7834-438-1 2024-07-10T08:08:51.162Z 44 yes 46 Rabiea Ashowen Ahmoda University of Belgrade Faculty of Technology and Metallurgy Milena Milosevic University of Belgrade, Institute of Chemistry, Technology and Metallurgy IHTM Serbia person Petar Batinić Institute for Medicinal Plants Research “Dr Josif Pančić”, Belgrade, Serbia person Andrea Pirković University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-1182-4895 Aleksandar Krstić University of Belgrade, VINČA INSTITUTE OF NUCLEAR SCIENCES, Serbia person Aleksandar Marinković University of Belgrade, Faculty of Technology and Metallurgy, Serbia person Aleksandra A. Jovanović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor tehnoloških nauka person 0000-0001-5394-0125 application/pdf 474910 https://phaidrabg.bg.ac.rs/o:34254 no yes 19 70 92000004 11A24 11A28 11A29 11A41 Encapsulation of Fumaria officinalis extract in the liposomal vesicles 91 Book of Abstracts 3rd UNIFood International Conference – UNIFood2024 Belgrade, Serbia 2024