human trophoblast cells, reactive oxygen species (ROS), oleuropein (OLE) Oleuropein treatment attenuates ROS generation, inflammation, and H2O2-induced damage in human trophoblast cells application/pdf 367509 bytes info:eu-repo/semantics/conferenceProceedings http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode ABSTRACT Higher energy demands during pregnancy lead to enhanced oxidative phosphorylation and increased production of reactive oxygen species (ROS) which have been shown to act as important regulators of angiogenesis, proliferation, differentiation and invasion of placental cells-trophoblast, autophagy and other important physiological processes and tissue adaptations. This controlled placental oxidative stress and inflammatory response are essential for successful early pregnancy. However, unbalanced, excessive ROS production has adverse effects on pregnancy outcome, causing trophoblast cell damage and dysfunction. Antioxidant supplements have been proposed as a possible approach in the prevention and treatment of such disorders. EPHAR 2024 Abstract Book-9th European Congress of Pharmacology eng https://phaidrabg.bg.ac.rs/o:34135 EPHAR-The Federation of European Pharmacological Societies Pirković, Andrea Vilotić, Aleksandra Nacka-Aleksić, Mirjana Bojić-Trbojević, Žanka Jovanović Krivokuća, Milica Dekanski, Dragana 2024