o:34047 Caffeic acid downregulates HIF1A and VEGF receptors modulating endothelial-like properties of human trophoblast cells en ABSTRACT Caffeic acid (CA) is a polyphenolic compound widely present in fruits, vegetables, spices and beverages used in everyday diet. Numerous research indicated beneficial effects of CA on human health including its antioxidant, anti-inflammatory and anticancer activities. Nevertheless, data about the effects of CA in pregnancy, especially on early pregnancy events, are limited. Remodeling of uterine spiral arteries together with trophoblast endovascular differentiation are critical processes for establishing and maintaining a healthy pregnancy. The aim of this study is to investigate how CA affects trophoblast endothelial-like properties assessed with tube formation assay on Matrigel, an in vitro angiogenesis assay. 1552101 2566-2937 2024-06-18T10:10:07.396Z 44 yes 46 Aleksandra Vilotić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka 0000-0002-0898-5401 Dragana Dekanski University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor medicinskih nauka person 0000-0001-8467-4165 Milica Jovanović Krivokuća University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-8292-4853 application/pdf 2386067 https://phaidrabg.bg.ac.rs/o:34047 no yes 18 70 92000004 11A29 11A2901 Genetics and Applications-Special Edition An Aspiring Interdisciplinary Journal of Genetic Research-Book of Abstracts, 2nd European Symposium on Phytochemicals in Medicine and Food, Sarajevo, Bosnia and Herzegovina The Institute for Genetic Engineering and Biotechnology, University of Sarajevo 2024