http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode eng https://phaidrabg.bg.ac.rs/o:34047 ISSN: 2566-2937 ABSTRACT Caffeic acid (CA) is a polyphenolic compound widely present in fruits, vegetables, spices and beverages used in everyday diet. Numerous research indicated beneficial effects of CA on human health including its antioxidant, anti-inflammatory and anticancer activities. Nevertheless, data about the effects of CA in pregnancy, especially on early pregnancy events, are limited. Remodeling of uterine spiral arteries together with trophoblast endovascular differentiation are critical processes for establishing and maintaining a healthy pregnancy. The aim of this study is to investigate how CA affects trophoblast endothelial-like properties assessed with tube formation assay on Matrigel, an in vitro angiogenesis assay. 2024 application/pdf 2386067 bytes The Institute for Genetic Engineering and Biotechnology, University of Sarajevo Genetics and Applications-Special Edition Caffeic acid downregulates HIF1A and VEGF receptors modulating endothelial-like properties of human trophoblast cells info:eu-repo/semantics/conferenceProceedings Vilotić, Aleksandra Dekanski, Dragana Jovanović Krivokuća, Milica