o:33792 Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats Sokovi crne ribizle i drena bogati polifenolima pozitivno deluju na metabolički sindrom Vistar pacova izazvan dijetom bogatom mastima i fruktozom en ABSTRACT Diets high in fat and sugar lead to metabolic syndrome (MetS) and related chronic diseases. We investigated the effects of commercially available, cold-pressed polyphenol-rich black currant (BC) and cornelian cherry (CC) juices on the prevention of MetS in Wistar rats induced by a 10-weeks high-fat high-fructose (HFF) diet. Juice consumption, either BC or CC, with a HFF diet resulted in lower serum triglycerides compared to only the HFF consumption. Both juices also mitigated the effects of HFF on the liver, pancreas, and adipose tissue, by preserving liver and pancreas histomorphology and reducing visceral fat and adipocyte size. Furthermore, supplementation with both juices reduced glucagon and up-regulated insulin expression in the pancreas of the rats on the HFF diet, whereas the BC also showed improved glucose regulation. BC juice also reduced the expression of IL-6 and hepatic inflammation compared to the group only on HFF diet. Both juices, especially BC, could be a convenient solution for the prevention of MetS in humans. Metabolic syndrome, Polyphenol-rich juices, Black currant, Cornelian cherry, High-fat high-fructose diet, Animal model 1552099 10.1016/j.heliyon.2024.e27709 2024-05-24T11:55:29.174Z 44 yes 46 Marija Paunović Group for Nutritional Biochemistry and Dietology, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Serbia Maja Milošević Group for Neuroendocrinology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Serbia person Olivera Mitrović-Ajtić Group for Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Serbia person Nataša Veličković Department of Biochemistry, Institute for Biological Research "Siniša Stanković", National Institute of the Republic of Serbia, University of Belgrade, Serbia person Bojana Mićić Department of Biochemistry, Institute for Biological Research "Siniša Stanković", National Institute of the Republic of Serbia, University of Belgrade, Serbia person Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-2042-0056 Vanja Todorović Department of Bromatology, University of Belgrade-Faculty of Pharmacy, Serbia person Vesna Vučić Group for Nutritional Biochemistry and Dietology, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Serbia person Snježana Petrović Group for Nutritional Biochemistry and Dietology, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Serbia person application/pdf 1642471 https://phaidrabg.bg.ac.rs/o:33792 no yes 16 70 92000001 11A25 11A29 11A2905 11A21 11A13 11A1304 Heliyon 10 7 Elsevier 2024