o:33788 A Prospective Observational Study Analyzing the Diagnostic Value of Hepcidin-25 for Anemia in Patients with Inflammatory Bowel Diseases Prospektivna obzervaciona studija koja analizira dijagnostičku vrednost hepcidina-25 u anemiji kod pacijenata sa inflamatornim bolestima creva en ABSTRACT Iron deficiency (IDA) and chronic disease (ACD) anemia are complications of inflammatory bowel diseases (IBDs). Therapeutic modalities in remission and active IBD depend on the type of anemia. This study evaluated the link between hepcidin-25, proinflammatory cytokines, and platelet activation markers as biomarkers of anemia and inflammation in active IBD and remission. This prospective observational study included 62 patients with IBD (49 with ulcerative colitis and 13 with Crohn’s) and anemia. Patients were divided into Group I (no or minimal endoscopic signs of disease activity and IDA), Group II (moderate and major endoscopic signs of disease activity and mild ACD), and Control group (10 patients with IBD in remission, without anemia). We assessed the difference among groups in the levels of CRP, hemoglobin (Hgb), serum iron, ferritin, hepcidin-25, interleukins, TNF–α, IFN-γ, soluble CD40 ligand, and sP-selectin. Hepcidin-25 levels were significantly higher in Group II versus Group I (11.93 vs. 4.48 ng/mL, p < 0.001). Ferritin and CRP values showed similar patterns in IBD patients: significantly higher levels were observed in Group II (47.5 ng/mL and 13.68 mg/L) than in Group I (11.0 ng/mL and 3.39 mg/L) (p < 0.001). In Group II, hepcidin-25 was positively correlated with ferritin (ρ = 0.725, p < 0.001) and CRP (ρ = 0.502, p = 0.003). Ferritin was an independent variable influencing hepcidin-25 concentration in IBD patients, regardless of disease activity and severity of anemia. IBD hepcidin-25 best correlates with ferritin, and both parameters reflected inflammation extent and IBD activity. hepcidin; ferritin; ulcerative colitis; Crohn’s disease; anemia; inflammation; cytokine 1552099 10.3390/ijms25073564 2024-05-24T10:54:22.928Z 44 yes 46 Stanko Petrović University of Defence, Medical Faculty of the Military Medical Academy, Belgrade, Serbia Dino Tarabar University Hospital Center “Dr. Dragiša Mišović”, Clinic for Gastroenterology, Belgrade, Serbia person Danica Ćujić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor medicinskih nauka-farmacija person 0000-0002-6145-3850 Dušica Stamenković University of Defence, Medical Faculty of the Military Medical Academy, Belgrade, Serbia person Marijana Petrović University of Defence, Medical Faculty of the Military Medical Academy, Belgrade, Serbia person Nemanja Rančić University of Defence, Centre for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia person Vesna Subota University of Defence, Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia person Nenad Perišić University of Defence, Medical Faculty of the Military Medical Academy, Belgrade, Serbia person Mihailo Bezmarević University of Defence, Medical Faculty of the Military Medical Academy, Belgrade, Serbia person application/pdf 1403928 https://phaidrabg.bg.ac.rs/o:33788 no yes 16 1556227 70 92000001 11A29 11A2910 International Journal of Molecular Sciences 25 7 MDPI 2024