o:32244 Evaluation of the anti-inflammatory potential of Paeonia tenuifolia L. petal extract en Paeonia tenuifolia L. is a perennial, herbaceous plant species, known for the medicinal value of all of its parts. This study is aimed at determining the anti-inflammatory activity of the petals from P. tenuifolia L. wild-growing in Gulenovci, Serbia. The extract was prepared using the maceration method, and methyl alcohol as the extraction solvent, after which the sample was filtered through a filter paper, and dried to a constant mass using a drying oven. The anti-inflammatory activity of the extract was assessed based on the inhibition of protein denaturation under the influence of elevated temperatures. P. tenuifolia L. petal extract (250–1000 µg/mL) achieved a significant in vitro inhibition of the bovine serum albumin (BSA) denaturation, in a dose-dependent manner. The obtained results were compared to a reference drug, ibuprofen (20-100 µg/mL). The petal extract showed the highest antiinflammatory potential at a concentration of 250 µg/mL, with 80.07 ± 1.33% of inhibition, while the lowest level of inhibition was achieved at the highest tested concentration (54.33 ± 2.33%). This type of findings highlight the potential use of P. tenuifolia petal extracts in pharmaceutical and cosmetic industries, for the treatment of skin inflammation. 1552100 978-86-80321-38-7 2024-01-03T10:08:32.414Z 44 yes 46 Natalija Čutović Institute for Medicinal Plants Research “Dr Josif Pančić”, Belgrade, Serbia Tatjana Marković Institute for Medicinal Plants Research “Dr Josif Pančić”, Belgrade, Serbia person Tamara Carević Institute for Biological Research “Siniša Stanković”—National Institute of Republic of Serbia, University of Belgrade, Serbia person Dejan Stojković Institute for Biological Research “Siniša Stanković”—National Institute of Republic of Serbia, University of Belgrade, Serbia person Branko Bugarski University of Belgrade, Faculty of Technology and Metallurgy, Serbia person Aleksandra Jovanović Institute for the Application of Nuclear Energy INEP, University of Belgrade, Serbia doktor nauka person 0000-0001-5394-0125 application/pdf 996816 https://phaidrabg.bg.ac.rs/o:32244 no yes 19 70 92000004 11A21 11A41 11A29 Evaluation of the anti-inflammatory potential of Paeonia tenuifolia L. petal extract 5 Twenty-First Young Researchers Conference – Materials Science and Engineering 2023-12-01