https://phaidrabg.bg.ac.rs/o:32244 http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode Evaluation of the anti-inflammatory potential of Paeonia tenuifolia L. petal extract info:eu-repo/semantics/conferenceProceedings application/pdf 996816 bytes Evaluation of the anti-inflammatory potential of Paeonia tenuifolia L. petal extract Čutović, Natalija Marković, Tatjana Carević, Tamara Stojković, Dejan Bugarski, Branko Jovanović, Aleksandra eng Paeonia tenuifolia L. is a perennial, herbaceous plant species, known for the medicinal value of all of its parts. This study is aimed at determining the anti-inflammatory activity of the petals from P. tenuifolia L. wild-growing in Gulenovci, Serbia. The extract was prepared using the maceration method, and methyl alcohol as the extraction solvent, after which the sample was filtered through a filter paper, and dried to a constant mass using a drying oven. The anti-inflammatory activity of the extract was assessed based on the inhibition of protein denaturation under the influence of elevated temperatures. P. tenuifolia L. petal extract (250–1000 µg/mL) achieved a significant in vitro inhibition of the bovine serum albumin (BSA) denaturation, in a dose-dependent manner. The obtained results were compared to a reference drug, ibuprofen (20-100 µg/mL). The petal extract showed the highest antiinflammatory potential at a concentration of 250 µg/mL, with 80.07 ± 1.33% of inhibition, while the lowest level of inhibition was achieved at the highest tested concentration (54.33 ± 2.33%). This type of findings highlight the potential use of P. tenuifolia petal extracts in pharmaceutical and cosmetic industries, for the treatment of skin inflammation. 2023-12-01