o:32095 Challenges and current advances in the methodology of thyroglobulin measurements Izazovi i savremeni napreci u metodologiji merenja tiroglobulina en ABSTRACT Thyroglobulin (Tg) is a large protein secreted exclusively by the thyroid gland. In a clinical setting, it is measured for the purpose of follow-up of thyroidectomy patients. However, Tg measurements are often impeded by the presence of Tg autoantibodies and/or heterophylic antibodies that interfere with most measuring platforms. This presents a global problem in thyroid cancer patients who need to be postoperatively monitored for recurrent or residual disease. Therefore, in this paper we offer an overview of the existing methodologies and alternative approaches for Tg measurements that are a focus of research worldwide. These include Tg mRNA measurements, exosomal Tg detection, the use of alternative analytes (liquid biopsies) and the development of new approaches for preanalytical sample treatment. antibody interference; extracellular vesicles; immunoassays; liquid biopsies; preanalytical treatment; thyroglobulin 2023-12-19T13:56:10.923Z 44 yes 46 Ilona Đorić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka 0000-0001-5322-4559 Sonja Šelemetjev University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-2898-6671 application/pdf 8480 https://phaidrabg.bg.ac.rs/o:32095 no yes 18 70 92000001 11A29 11A2902 Bioanalysis 16 1 49 60 Future Science Group 2023