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    <ns1:title language="sr">Profilisanje površinskog glkozilovanja mikroorganizama biljnim lektinima</ns1:title>
    <ns2:subtitle language="sr">doktorska disertacija</ns2:subtitle>
    <ns2:alt_title language="en">Profiling surface glycosylation of microorganisms using plant lectins : doctoral dissertation</ns2:alt_title>
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    <ns1:description language="sr">Interakcije između mikroorganizama i domaćina imaju glavnu ulogu u infekciji iprogresiji infektivnih bolesti. Upravo zbog toga postoji opravdana potreba da se identifikuju iokarakterišu sve komponente koje učestvuju u toj interakciji. Procesom glikozilacije napovršini svih mikroorganizima formira se jedinstvena arhitektura površinskih polisaharidnihstruktura i upravo ovaj proces smatra se ključnim faktorom virulencije mnogihmikroorganizama.Površinske polisaharidne strukture mikroorganizama su značajne jer ostvaruju direktankontakt sa “receptorskim” strukturama na ćelijama domaćina i varijabilnim regionima antitela,ali prvenstveno u formiranju mehanizama za izbegavanje imunskog odgovora. Upravo ovepovršinske strukture igraju važnu ulogu prilikom prepoznavanja od strane imunskog sistemadomaćina, pa se tako vakcinacija protiv nekih patogenih mikroorganizama zasniva navakcinaciji polisaharidnim komponentama kovalentno vezanim za proteinske nosače...</ns1:description>
    <ns1:description language="en">The interaction between microorganisms and their potential host plays a major role ininfection and progression of infective diseases. To better understand those mechanisms, thereis a need to identify and characterize all the components involved in that interaction.Surface polysaccharide structures of microorganisms are unique in architecture, andthey are often key virulence factors of many microorganisms, which shield them from theimmune system and are involved in immune evasion mechanisms. In parallel, polysaccharidestructures found on the surface of microorganisms act as “receptor” structures for host cells oract as epitopes of antibacterial antibodies. This holds true, for example, for vaccination againstcertain pathogenic microorganisms which is based on polysaccharide components that arecovalently bound to protein carriers...</ns1:description>
    <ns1:description language="sr">Biohemija - Imunologija / Biochemistry - Immunology  
Datum odbrane: 20.12.2022. </ns1:description>
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