o:31386 Anticancer effects of non-toxic repurposed drugs on hamster fibrosarcoma – fast applicable in oncology en Abstract: Background. Some drugs developed for other illnesses might be repurposed for cancer treatment, to kill cancer cells by hitting previously recognized or unrecognized molecular target or unknown target. This study investigated such drugs, with proven in vitro anticancer effects, in vivo on fibrosarcoma in hamsters. Material and Methods. Anticancer efficacy of selected repurposed drugs: mebendazole, metformin, diclofenac, 2-Deoxy-D-glucose, deoxycholic acid, caffeine, itraconazole, nitroglycerin, disulfiram and selected two-component combinations were tested on fibrosarcoma experimentally induced by BHK-21/C13 cells in Syrian golden hamsters. Tumor biophysical characteristics, histology and immunohistochemistry were assessed. Blood samples were collected for hematological and biochemical analyses and the main organs were toxicologically analyzed. Results. This study showed that two-drug combinations: metformin with 2-Deoxy-D-glucose, metformin with deoxycholic acid, metformin with caffeine, metformin with itraconazole, metformin with nitroglycerin and metformin with disulfiram can significantly (P < 0.05) suppress fibrosarcoma in hamsters with doses equivalent to achievable oncological human doses, without toxicity and influence on biochemical and hematological tests. Conclusion. All efficacious repurposed drug combinations recorded in our study on hamster fibrosarcoma can be recommended for further clinical trials. Keywords : BHK-21/C13, cell culture, drug combinations, drug effects, fibrosarcoma, hamsters 1552101 3009-3848 1552102 https://www.sdir.ac.rs/pdf/Oncology_Insights_No_1_2023.pdf 2023-10-23T14:47:15.181Z 44 no 46 Dušica Popović J. Državni univerzitet u Novom Pazaru 0000-0001-7880-0874 Kosta Popović J. person 0000-0001-7895-9009 Dejan Miljković person 0000-0002-7739-5202 Dušan Lalošević person 0000-0002-0760-9180 Zana Dolićanin Državni univerzitet u Novom Pazaru person 2237799 0000-0003-0457-3087 Ivan Čapo person 0000-0001-7531-5099 Jovan Popović K. person 0000-0002-6790-8668 application/pdf 1398244 https://phaidrabg.bg.ac.rs/o:31386 no yes 1 70 92000004 20A01 Proceedings Book of the 6th Congress of the Serbian Association for Cancer Research – SDIR with international participation “From Collaboration to Innovation in Cancer Research”, October 2-4 2023, Belgrade, Serbia. Official Journal of the Serbian Association for Cancer Research Oncology Insights, October 2023;1(1): 94-95 (P38) 1 1 94 95 2023