
<ns0:uwmetadata xmlns:ns0="http://phaidra.univie.ac.at/XML/metadata/V1.0" xmlns:ns1="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0" xmlns:ns10="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0" xmlns:ns11="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0/entity" xmlns:ns12="http://phaidra.univie.ac.at/XML/metadata/digitalbook/V1.0" xmlns:ns13="http://phaidra.univie.ac.at/XML/metadata/etheses/V1.0" xmlns:ns2="http://phaidra.univie.ac.at/XML/metadata/extended/V1.0" xmlns:ns3="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/entity" xmlns:ns4="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/requirement" xmlns:ns5="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/educational" xmlns:ns6="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/annotation" xmlns:ns7="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/classification" xmlns:ns8="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/organization" xmlns:ns9="http://phaidra.univie.ac.at/XML/metadata/histkult/V1.0">
  <ns1:general>
    <ns1:identifier>o:31330</ns1:identifier>
    <ns1:title language="en">Repurposed drug combinations that efficaciously inhibit fibrosarcoma induced by BHK-21/C13 in hamsters</ns1:title>
    <ns1:language>en</ns1:language>
    <ns1:description language="en">Abstract:
A large diversity in molecular mechanisms of cancer regulation allows some marketed pleiotropic non-oncological non-toxic pharmaceuticals to be used in oncology, what reduce duration and cost of novel anticancer treatment research. By docking data of biomolecular activities of nontoxic non-oncological drugs with anticancer targets, we have chosen some promising combinations for further screening on fibrosarcoma in hamsters and separated combinations for possible use in oncology. For each repurposed drug – component of efficacious combination, identification of known anticancer mechanisms was found in the literature and jointly compared.</ns1:description>
    <ns1:keyword language="sr">Keywords : BHK-21/C13, repurposed drugs, fibrosarcoma, hamsters, NF-kB.</ns1:keyword>
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      <ns2:resource>1552100</ns2:resource>
      <ns2:identifier>978-86-7197-742-5</ns2:identifier>
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        <ns3:firstname>Dušica J.</ns3:firstname>
        <ns3:lastname>Popović</ns3:lastname>
        <ns3:institution>Državni univerzitet u Novom Pazaru</ns3:institution>
        <ns3:orcid>0000-0001-7880-0874 </ns3:orcid>
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        <ns3:firstname>Kosta J.</ns3:firstname>
        <ns3:lastname>Popović</ns3:lastname>
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        <ns3:lastname>Dolićanin</ns3:lastname>
        <ns3:institution>Državni univerzitet u Novom Pazaru</ns3:institution>
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        <ns3:firstname>Ivan</ns3:firstname>
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        <ns3:firstname>Jovan K. </ns3:firstname>
        <ns3:lastname>Popović</ns3:lastname>
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        <ns3:orcid>0000-0002-6790-8668</ns3:orcid>
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  <ns12:digitalbook>
    <ns12:name_magazine language="en">JCMST 2023 - The 2nd PSU-UNS Joint Conference on Medical Science and Technology, 11-13 October 2023</ns12:name_magazine>
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